The Efferent Medial Olivocochlear-Hair Cell Synapse
Identifieur interne : 000243 ( Main/Exploration ); précédent : 000242; suivant : 000244The Efferent Medial Olivocochlear-Hair Cell Synapse
Auteurs : Ana Belén Elgoyhen [Argentine] ; Eleonora Katz [Argentine]Source :
- Journal of Physiology, Paris [ 0928-4257 ] ; 2011.
Abstract
Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.
Url:
DOI: 10.1016/j.jphysparis.2011.06.001
PubMed: 21762779
PubMed Central: 3213294
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000239
- to stream Pmc, to step Curation: 000239
- to stream Pmc, to step Checkpoint: 000133
- to stream Ncbi, to step Merge: 000220
- to stream Ncbi, to step Curation: 000220
- to stream Ncbi, to step Checkpoint: 000220
- to stream Main, to step Merge: 000246
- to stream Main, to step Curation: 000243
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Efferent Medial Olivocochlear-Hair Cell Synapse</title><author><name sortKey="Elgoyhen, Ana Belen" sort="Elgoyhen, Ana Belen" uniqKey="Elgoyhen A" first="Ana Belén" last="Elgoyhen">Ana Belén Elgoyhen</name><affiliation wicri:level="1"><nlm:aff id="A1">Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Tercera Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Tercera Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, 1428 Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Katz, Eleonora" sort="Katz, Eleonora" uniqKey="Katz E" first="Eleonora" last="Katz">Eleonora Katz</name><affiliation wicri:level="1"><nlm:aff id="A1">Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21762779</idno><idno type="pmc">3213294</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213294</idno><idno type="RBID">PMC:3213294</idno><idno type="doi">10.1016/j.jphysparis.2011.06.001</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000239</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000239</idno><idno type="wicri:Area/Pmc/Curation">000239</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000239</idno><idno type="wicri:Area/Pmc/Checkpoint">000133</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000133</idno><idno type="wicri:Area/Ncbi/Merge">000220</idno><idno type="wicri:Area/Ncbi/Curation">000220</idno><idno type="wicri:Area/Ncbi/Checkpoint">000220</idno><idno type="wicri:doubleKey">0928-4257:2011:Elgoyhen A:the:efferent:medial</idno><idno type="wicri:Area/Main/Merge">000246</idno><idno type="wicri:Area/Main/Curation">000243</idno><idno type="wicri:Area/Main/Exploration">000243</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Efferent Medial Olivocochlear-Hair Cell Synapse</title><author><name sortKey="Elgoyhen, Ana Belen" sort="Elgoyhen, Ana Belen" uniqKey="Elgoyhen A" first="Ana Belén" last="Elgoyhen">Ana Belén Elgoyhen</name><affiliation wicri:level="1"><nlm:aff id="A1">Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Tercera Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Tercera Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, 1428 Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Katz, Eleonora" sort="Katz, Eleonora" uniqKey="Katz E" first="Eleonora" last="Katz">Eleonora Katz</name><affiliation wicri:level="1"><nlm:aff id="A1">Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Physiology, Paris</title><idno type="ISSN">0928-4257</idno><idno type="eISSN">1769-7115</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca<sup>2+</sup> permeable and is coupled to a Ca<sup>2+</sup>-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.</p></div></front></TEI><affiliations><list><country><li>Argentine</li></country></list><tree><country name="Argentine"><noRegion><name sortKey="Elgoyhen, Ana Belen" sort="Elgoyhen, Ana Belen" uniqKey="Elgoyhen A" first="Ana Belén" last="Elgoyhen">Ana Belén Elgoyhen</name></noRegion><name sortKey="Elgoyhen, Ana Belen" sort="Elgoyhen, Ana Belen" uniqKey="Elgoyhen A" first="Ana Belén" last="Elgoyhen">Ana Belén Elgoyhen</name><name sortKey="Katz, Eleonora" sort="Katz, Eleonora" uniqKey="Katz E" first="Eleonora" last="Katz">Eleonora Katz</name><name sortKey="Katz, Eleonora" sort="Katz, Eleonora" uniqKey="Katz E" first="Eleonora" last="Katz">Eleonora Katz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Eau/explor/LotaV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000243 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000243 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Eau
|area= LotaV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3213294
|texte= The Efferent Medial Olivocochlear-Hair Cell Synapse
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21762779" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LotaV3
| This area was generated with Dilib version V0.6.39. |  |